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KMID : 0378019710140120077
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New Medical Journal
1971 Volume.14 No. 12 p.77 ~ p.88
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Effect of Acute CO Intoxication on the Pulmonary Surfactant in Rabbits
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Abstract
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In order to observe a possible effect of CO intoxication on the activities of surfactant, the rabbit was exposed to 0. 1, 0.2 and 0.4% CO gas for two to six hours and the lung extract was prepared.
The tension-area diagram of the lung extract was recorded automatically using the modified Langmuir￢Wilhelmy balance with a synchronized recording system, and the results were compared with control (i.e. : non-CO gas exposed normal rabbits).
The results obtained are summarized as follows:
1. The maximal surface tension, minimal surface tension, width of the tension-area diagram at thee surface area of 40%, and stability index of the normal rabbit lung extracts were 31.6±3. 11 dynes/cm, . 8.2±0.56 dynes/cm, 21.4±4.40 dynes/cm and 1.12±0.22, respectively.
2. In the acute CO intoxication group,
a) the activities of surfactant did not show any significant difference from the control when the animal was exposed to 0. 1, 0. 2, and 0.4% CO gas for two hours.
b) Where the animal was exposed to 0.2% CO gas for two and six hours, the maximal surface tension for two and six hours, the maximal surface tension and width were found to be similar to those of the control, while the minimal surface tension showed a slight decrease and stability index a slight increase. However, the difference was not statistically significant.
3. When the animal was exposed to 0. 1, 0.2 and 0.4% CO gas ranging for two to six hours, the acti- ; vities of surfactant showed no appreciable difference comparing with the normal.
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